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1. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR ... - PubMed
nih.gov
Link: https://pubmed.ncbi.nlm.nih.gov/26422227/
Description: WEBOct 22, 2015 · Here, we report characterization of Cpf1, a putative class 2 CRISPR effector. We demonstrate that Cpf1 mediates robust DNA interference with features distinct from Cas9. Cpf1 is a single RNA-guided endonuclease lacking tracrRNA, and it utilizes a T-rich protospacer-adjacent motif.
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2. Cas12a - Wikipedia
wikipedia.org
Link: https://en.wikipedia.org/wiki/Cas12a
Description: WEBCas12a (CRISPR associated protein 12a, previously known as Cpf1) is a subtype of Cas12 proteins and an RNA-guided endonuclease that forms part of the CRISPR system in some bacteria and archaea.
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3. CRISPR Cpf1 proteins: structure, function and implications for …
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6507119/
Description: WEBMay 9, 2019 · CRISPR-Cas systems are classified into two main classes and six types. Cpf1 is a putative type V (class II) CRISPR effector, which can be programmed with a CRISPR RNA to bind and cleave complementary DNA targets.
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4. Highly efficient genome editing by CRISPR-Cpf1 using CRISPR …
nature.com
Link: https://www.nature.com/articles/s41467-018-06129-w
Description: WEBSep 7, 2018 · 117 Citations. 17 Altmetric. Metrics. Genome editing has been harnessed through the development of CRISPR system, and the CRISPR from Prevotella and Francisella 1 (Cpf1) system has emerged as a...
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5. Cpf1 is a single RNA-guided endonuclease of a Class 2 CRISPR-Cas …
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638220/
Description: WEBOct 10, 2015 · Here we report characterization of Cpf1, a putative Class 2 CRISPR effector. We demonstrate that Cpf1 mediates robust DNA interference with features distinct from Cas9. Cpf1 is a single RNA-guided endonuclease lacking tracrRNA, and it utilizes a T-rich protospacer adjacent motif.
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6. The crystal structure of Cpf1 in complex with CRISPR RNA
nature.com
Link: https://www.nature.com/articles/nature17944
Description: WEBApr 20, 2016 · The CRISPR–Cpf1 system, a new class 2 CRISPR–Cas system, mediates robust DNA interference in human cells 1, 8, 9, 10. Although functionally conserved, Cpf1 and Cas9 differ in many aspects...
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7. CRISPR-Cpf1 mediates efficient homology-directed repair and
nature.com
Link: https://www.nature.com/articles/s41467-017-01836-2
Description: WEBDec 8, 2017 · Cpf1 is a newly discovered class 2/type V CRISPR-Cas DNA endonuclease 1 that displays a range of activity across different systems. Thus far, two Cpf1 proteins have been used for genome editing...
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8. CRISPR Cpf1 proteins: structure, function and implications for …
nih.gov
Link: https://pubmed.ncbi.nlm.nih.gov/31086658/
Description: WEBMay 9, 2019 · Cpf1 has recently emerged as an alternative for Cas9, due to its distinct features such as the ability to target T-rich motifs, no need for trans-activating crRNA, inducing a staggered double-strand break and potential for both RNA processing and DNA nuclease activity.
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9. Cpf1 Is A Versatile Tool for CRISPR Genome Editing Across …
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175191/
Description: WEBDec 21, 2016 · Cpf1 is a type V-A nuclease of the class II family of CRISPR systems 16. Cfp1 is not homologous to the commonly used CRISPR nuclease, Cas9 and employs a mechanism that is different from that of Cas9 17. As such, there are several major differences between cas9 and cpf1 systems.
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10. Frontiers | The Rise of the CRISPR/Cpf1 System for Efficient …
frontiersin.org
Link: https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2020.00264/full
Description: WEBMar 31, 2020 · The CRISPR/Cpf1 system enables gene deletion, insertion, base editing, and locus tagging in monocot as well as in dicot plants with fewer off-target effects. This tool has been efficiently demonstrated into tobacco, rice, soybean, wheat, etc.