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1. Costello syndrome - About the Disease - Genetic and Rare …
Link: https://rarediseases.info.nih.gov/diseases/1550/costello-syndrome/
Description: WebCostello syndrome is a rare condition that affects many different parts of the body. Signs and symptoms generally include developmental delay, intellectual disability, distinctive facial features, loose folds of extra skin (especially on the …
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2. Costello Syndrome: Symptoms, Causes, Diagnosis & Treatment
Link: https://my.clevelandclinic.org/health/diseases/costello-syndrome
Description: WebCostello syndrome is a rare genetic condition that causes cells to divide and replicate faster than expected. This causes both cancerous and noncancerous tumors to form. Costello syndrome also affects the brain, bones, heart, muscles and skin. Treatment addresses symptoms of the condition and there’s no cure.
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3. Costello syndrome: Clinical phenotype, genotype, and …
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238015/
Description: WebSUMMARY. Costello syndrome (CS) is a RASopathy due to activating germline mutations in the gene HRAS. Due to the ubiquitous nature in which HRAS is expressed, CS is a complex syndrome affecting multiple organ systems and individuals are predisposed to …
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4. Costello syndrome - Wikipedia
Link: https://en.wikipedia.org/wiki/Costello_syndrome
Description: WebCostello syndrome, also called faciocutaneoskeletal syndrome or FCS syndrome, is a rare genetic disorder that affects many parts of the body. It is characterized by delayed development and intellectual disabilities, distinctive facial features, unusually flexible joints, and loose folds of extra skin, especially on the hands and feet.
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5. Costello Syndrome - Symptoms, Causes, Treatment | NORD
Link: https://rarediseases.org/rare-diseases/costello-syndrome/
Description: WebJan 4, 2017 · Costello syndrome is an extremely rare disorder that affects multiple organ systems of the body. This condition is characterized by growth delays after birth; short stature; extra loose skin on the neck, palms of the hands, fingers, and soles of the feet; noncancerous tumors (papillomata) around the face and anus; developmental delay and ...
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6. Costello syndrome: MedlinePlus Genetics
Link: https://medlineplus.gov/genetics/condition/costello-syndrome/
Description: WebDescription. Costello syndrome is a rare disorder that affects many parts of the body. This condition is characterized by delayed development, loose folds of skin (which are especially noticeable on the hands and feet), unusually flexible joints, heart problems, short stature, and distinctive facial features. Children with Costello syndrome are ...
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7. Costello Syndrome: Causes and Symptoms - Massachusetts General Hospital
Link: https://www.massgeneral.org/children/costello-syndrome
Description: WebWhat is Costello Syndrome? Costello syndrome is a genetic disorder that affects your child’s appearance, development, growth and intellect. It can also affect your child’s heart, skin and joints. What Causes Costello Syndrome? Costello syndrome is caused by a mutation (change) in the HRAS gene (piece of DNA). In most cases, the change ...
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8. Costello Syndrome | Costello Syndrome Family Network (CSFN)
Link: https://costellosyndromeusa.org/what-is-costello-syndrome/
Description: WebQuick Facts about Costello syndrome: Costello syndrome (CS) is a rare, genetic disorder that affects many parts of the body. There is no cure. Costello syndrome causes neurocognitive delays and impaired learning. Many children struggle to …
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9. About: Costello syndrome
Link: https://rarediseases.oscar.ncsu.edu/disease/costello-syndrome/about/
Description: WebCostello syndrome is a disorder that affects many parts of the body. This condition is characterized by delayed development and intellectual disability, loose folds of skin (which are especially noticeable on the hands and feet), unusually flexible joints, and distinctive facial features including a large mouth.
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10. RASopathies Costello Syndrome - National Cancer Institute
Link: https://rasopathies.cancer.gov/syndromes/costello.html
Description: WebCostello Syndrome (CS) is a genetic disorder caused by variants in a gene called HRAS. CS is rare and affects about one in 300,000 to one in 1.25 million individuals. Individuals with CS have an estimated 15% lifetime risk of developing cancer, particularly in soft tissue such as muscle (rhabdomyosarcoma).
