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1. Beta-secretase 1 - Wikipedia
wikipedia.org
Link: https://en.m.wikipedia.org/wiki/Beta-secretase_1
Description: WEBBeta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 (BACE1), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene.
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2. BACE1: More than just a β‐secretase - PMC - National Center for
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286785/
Description: WEBFeb 4, 2022 · Summary. β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has historically focused on its actions as the β‐secretase responsible for the production of β‐amyloid beta, observed in Alzheimer's disease. Although the greatest expression of BACE1 is found in the brain, BACE1 mRNA and …
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3. The β-Secretase BACE1 in Alzheimer's Disease - PubMed
nih.gov
Link: https://pubmed.ncbi.nlm.nih.gov/32223911/
Description: WEBApr 15, 2021 · BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ 42, which aggregates into bioactive conformational species and likely initiates toxicity in Alzheimer's disease (AD).
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4. The β-Secretase BACE1 in Alzheimer’s Disease - PMC
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533042/
Description: WEBApr 1, 2021 · BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ 42, which aggregates into bioactive conformational species and likely initiates toxicity in Alzheimer’s disease (AD).
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5. BACE1 controls synaptic function through modulating release of …
nature.com
Link: https://www.nature.com/articles/s41380-021-01166-2
Description: WEBJun 22, 2021 · We show that BACE1 is required for optimal release of synaptic vesicles. BACE1 deficiency or inhibition decreases synaptic vesicle docking in the synaptic active zones.
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6. BACE1: from biomarker to Alzheimer’s disease therapeutical target
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8148506/
Description: WEBMay 5, 2021 · Amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation in the brain . The BACE1 cleavage of APP results in a deviation of the physiological non-amyloidogenic pathway, driven by α-secretase, leading to the formation of two peptides, the soluble ectodomain APPsβ and the ...
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7. BACE1: More than just a β-secretase - PubMed
nih.gov
Link: https://pubmed.ncbi.nlm.nih.gov/35119166/
Description: WEBβ-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions as the β-secretase responsible for the production of β-amyloid beta, observed in Alzheimer's disease. Although the greatest expression of BACE1 is found in the brain, BACE1 mRNA and protein is ….
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8. The beta secretase BACE1 regulates the expression of insulin
nature.com
Link: https://www.nature.com/articles/s41467-018-03755-2
Description: WEBApr 3, 2018 · Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent manner, both in ...
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9. BACE1 in PV interneuron tunes hippocampal CA1 local circuits
nature.com
Link: https://www.nature.com/articles/s41380-023-02176-y
Description: WEBJul 14, 2023 · Abstract. BACE1 is the rate-limiting enzyme for β-amyloid (Aβ) production and therefore is considered a prime drug target for treating Alzheimer’s disease (AD). Nevertheless, the BACE1 ...
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10. BACE1: A Key Regulator in Alzheimer's Disease Progression and …
nih.gov
Link: https://pubmed.ncbi.nlm.nih.gov/34852746/
Description: WEBConclusion: BACE1 is involved in the progression of AD. The current ongoing or failed clinical trials may help understand the role of BACE1 inhibition in regulating the Aβ load and cognitive status of AD patients. Keywords: Alzheimer’s disease; Aβ42 peptide; BACE1; Beta-secretase; inhibitors; neurodegenerative disease.
