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1. Principles of antimicrobial therapy of Pseudomonas ... - UpToDate
uptodate.com

Link: https://www.uptodate.com/contents/principles-of-antimicrobial-therapy-of-pseudomonas-aeruginosa-infections

Description: WebFeb 6, 2024 · Pseudomonas aeruginosa is a key gram-negative aerobic bacillus in the differential diagnosis of a number of infections. This organism is important because it is often antibiotic resistant and can cause severe hospital-acquired infections associated with a high mortality rate, especially in immunocompromised hosts.
2. IDSA 2023 Guidance on the Treatment of Antimicrobial Resistant …
idsociety.org

Link: https://www.idsociety.org/practice-guideline/amr-guidance/

Description: WebSuggested approach: Meropenem, imipenem-cilastatin, or ertapenem are preferred for the treatment of infections outside of the urinary tract caused by ESBL-E. For patients who are critically ill and/or experiencing hypoalbuminemia, meropenem or imipenem-cilastatin are the preferred carbapenems.
3. Evidence-Based Treatment of Pseudomonas aeruginosa …
nih.gov

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9952410/

Description: WebFeb 16, 2023 · Meropenem-vaborbactam is a carbapenem/non-beta-lactam beta-lactamase inhibitor combination showing activities similar to simple meropenem in P. aeruginosa infections, as meropenem resistance in P. aeruginosa is mostly a result of mechanisms not impacted by vaborbactam.
4. Anti-Infective Dosing Protocols: Meropenem, Cefepime, and …
nebraskamed.com

Link: https://www.nebraskamed.com/sites/default/files/documents/for-providers/asp/Dosing-Protocol-RPeducation.pdf

Description: Websputum isolates growing Pseudomonas aeruginosa were evaluated, and MICs were obtained via Sensititre susceptibility plates. Susceptible MIC (mg/L) MIC 50 (mg/L) MIC 90 (mg/L) Meropenem ≤ 1 ≤ 1 4 Cefepime ≤ 8 8 16 Piperacillin/tazobactam ≤ 64 8 ≥ 64 MIC50 = MIC needed to inhibit the growth of 50% of the isolates
5. New Drugs for the Treatment of Pseudomonas aeruginosa …
nih.gov

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9137685/

Description: WebApr 26, 2022 · Meropenem-vaborbactam is an antimicrobial combination of a well-known, broad spectrum carbapenem and a novel cyclic boronic acid β-lactamase inhibitor with a high affinity of serine residues which enables it to perform as a competitive inhibitor by forming a covalent bond with the β-lactamase without undergoing hydrolysis .
6. Medication Administration: Extended-Infusion Meropenem …
stanford.edu

Link: https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-Extended-Infusion-Meropenem.pdf

Description: WebMeropenem belongs to the antibiotic class of carbapenems, which are known to be broad-spectrum antibiotics effective against several drug-resistant organisms. Notably, meropenem remains a viable option with efficacy against extended-spectrum beta-lactamase (ESBL)-producing organisms and Pseudomonas aeruginosa.
7. Dosage Regimens for Meropenem in Children with Pseudomonas …
nih.gov

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070814/

Description: WebNov 20, 2019 · Dosage Regimens for Meropenem in Children with Pseudomonas Infections Do Not Meet Serum Concentration Targets - PMC. Journal List. Clin Transl Sci. v.13 (2); 2020 Mar. PMC7070814. As a library, NLM provides access to scientific literature.
8. Update on the Efficacy and Tolerability of Meropenem in the …
oup.com

Link: https://academic.oup.com/cid/article/47/Supplement_1/S41/305563

Description: WebSep 15, 2008 · Meropenem is a carbapenem antibiotic approved by the US Food and Drug Administration for the treatment of complicated skin and skin-structure infections, complicated intra-abdominal infections, and pediatric bacterial meningitis (in patients ⩾3 months of age).
9. Pseudomonas aeruginosa Infections Medication: Antibiotics - Medscape
medscape.com

Link: https://emedicine.medscape.com/article/226748-medication

Description: WebMar 3, 2023 · With the exception of cases involving febrile patients with neutropenia, in whom monotherapy with ceftazidime or a carbapenem (eg, imipenem, meropenem) is used, a 2-drug regimen is recommended....
10. Antibacterial activity of meropenem against Pseudomonas ... - PubMed
nih.gov

Link: https://pubmed.ncbi.nlm.nih.gov/9923514/

Description: WebAbstract. The in vitro effects of meropenem on Pseudomonas aeruginosa were examined by studying (i) the inhibitory and bactericidal concentrations of meropenem versus those of imipenem for clinical isolates; (ii) changes in bacterial morphology during in vitro culture; and (iii) release of endotoxin induced by meropenem compared with that ...