-
1. Introduction to Pragmatic Clinical Trials - Duke University
Link: https://dcricollab.dcri.duke.edu/sites/NIHKR/KR/Introduction%20to%20pragmatic%20clinical%20trials.pdf
Description: webPragmatic research is designed with input from health systems—and produces evidence that can be readily used to improve care. • By engaging health systems, providers, and patients as partners, pragmatic research accelerates the integration of …
-
2. Pragmatic clinical trials: Testing treatments in the real world
Link: https://www.nia.nih.gov/research/blog/2017/06/pragmatic-clinical-trials-testing-treatments-real-world
Description: webJun 7, 2017 · NIA is particularly interested in conducting additional pragmatic trials. Some of the studies now in progress include: PROVEN – a cluster-randomized control trial of an advance care planning video program for nursing home patients in 359 facilities within two health care systems.
-
3. Pragmatic randomized clinical trials: best practices and statistical
Link: https://link.springer.com/article/10.1007/s10742-018-0192-5
Description: webDec 1, 2018 · Abstract. Randomized clinical trials often serve the purpose of assessing the efficacy and safety of a compound. By combining real-world evidence and randomization, pragmatic randomized clinical trials (PrCTs) can be used to inform treatment effectiveness and healthcare decisions. PrCTs, referring to studies where several pragmatic elements …
-
4. Pragmatic research: an introduction for clinical practitioners
Link: https://academic.oup.com/fampra/article/37/3/424/5875565
Description: webJul 23, 2020 · Pragmatic study. Traditional clinical efficacy. Stakeholder involvement: Engaged in all study phases including study design, conducting the study, collecting data, interpreting results, disseminating findings: Limited engagement, often in response to investigator ideas or study subjects: Research design
-
5. Pragmatic clinical trial - Wikipedia
Link: https://en.wikipedia.org/wiki/Pragmatic_clinical_trial
Description: webA pragmatic clinical trial ( PCT ), sometimes called a practical clinical trial ( PCT ), [1] is a clinical trial that focuses on correlation between treatments and outcomes in real-world health system practice rather than focusing on proving causative explanations for outcomes, which requires extensive de confounding with inclusion and ...
-
6. Pragmatic Trials: Practical Answers to “Real World” Questions
Link: https://jamanetwork.com/journals/jama/fullarticle/2553436
Description: webThe concept of a “pragmatic” clinical trial was first proposed nearly 50 years ago as a study design philosophy that emphasizes answering questions of most interest to decision makers. 1 Decision makers, whether patients, physicians, or policy makers, need to know what they can expect from the available diagnostic or therapeutic options when app...
-
7. Understanding controlled trials: What are pragmatic trials? | The BMJ
Link: https://www.bmj.com/content/316/7127/285
Description: webJan 24, 1998 · By contrast, the design of a pragmatic trial reflects variations between patients that occur in real clinical practice and aims to inform choices between treatments. To ensure generalisability pragmatic trials should, so far as possible, represent the patients to whom the treatment will be applied.
-
8. NIH Collaboratory Rethinking Clinical Trials – The Living Textbook
Link: https://rethinkingclinicaltrials.org/
Description: webMar 5, 2024 · Pragmatic clinical trials that address questions of major public health importance and provide proof of concept for innovative pragmatic research designs. CORES. Working groups that support the conduct of NIH Collaboratory Trials and generate guidance addressing implementation challenges. DISTRIBUTED RESEARCH NETWORK.
-
9. Meta-research on pragmatism of randomized trials: rationale and design
Link: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-023-07474-y
Description: webJun 30, 2023 · PragMeta captures data on (1) trial and design characteristics (e.g., sample size, population, intervention/comparison, outcome, longitudinal structure, blinding), (2) effects estimates, and (3) various determinants of pragmatism (e.g., the use of routinely collected data) and ratings from established tools used to determine pragmatism (e.g ...
-
10. Real-world evidence: How pragmatic are randomized controlled trials
Link: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-018-1038-2
Description: webApr 3, 2018 · Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are critical to inform decision-making by patients, clinicians and policy-makers in real-world settings. Pragmatic RCTs assess effectiveness of available medicines, while explanatory RCTs assess efficacy of investigational medicines.