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1. Molecular Characterization of Notch1 Positive Progenitor ...
Description: Since this number is relatively small and Notch1 has been shown to contribute to ganglion cell fate specification, we suggested that Notch1 signaling may play a more significant role in RGC …
2. Notch1 and Notch2 collaboratively maintain radial glial ...
Description: Sep 01, 2021 · Our results revealed that Notch1 has an essential role in establishing the RGC pool during the early stage, whereas Notch1 and Notch2 subsequently exhibit a comparable function for …
3. PNAS Plus: Liver X receptor β regulates the development …
Description: Mar 20, 2018 · Notch1 signaling and Smad4 activating pathways contribute to RGC development in the developing DG (24 –26). After standardization to actin, the mean level of Notch1 in the hippocampus …
4. MicroRNA-137 regulates hypoxia-induced retinal …
Description: Hypoxia induced Notch1 expression and signaling activation, while blocking Notch signaling significantly aggravated hypoxia-induced cell apoptosis. Further data revealed that the pro-survival Akt signaling …
5. NOTCH1 gene: MedlinePlus Genetics
Description: The NOTCH1 gene provides instructions for making a protein called Notch1, a member of the Notch family of receptors. Receptor proteins have specific sites into which certain other proteins, called …
6. What is the function of Notch 1 in astroglia?
Description: This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. A deficiency can be associated with bicuspid aortic valve. There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.
7. What does Notch 1 and Notch 3 do?
Description: There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia. Notch 1, when activated before birth, induces radial glia differentiation, but postnatally induces the differentiation into astrocytes.
8. What are the functions of the NOTCH1 gene?
Description: It also plays a role in cell growth and division (proliferation), maturation (differentiation), and self-destruction (apoptosis). The protein produced from the NOTCH1 gene has such diverse functions that the gene is considered both an oncogene and a tumor suppressor.
9. What kind of gene is notch homolog 1?
Description: Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.