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1. The role of the PTEN/AKT Pathway in NOTCH1-induced
Description: Furthermore, our studies revealed that NOTCH1 induces upregulation of the PI3K-AKT pathway via HES1, which negatively controls the expression of PTEN. This regulatory circuitry is evolutionary …
2. Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic …
Description: NOTCH1 protein, human Proto-Oncogene Proteins Receptor, Notch1 Ubiquitin-Protein Ligases PTEN Phosphohydrolase PTEN protein, human GTP Phosphohydrolases NRAS protein, human Proto …
3. Mutational loss of PTEN induces resistance to NOTCH1
Description: Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias (T-ALL), making this receptor a promising target for drugs such as γ-secretase inhibitors, which block a proteolytic …
4. Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR …
Description: BBR dose-dependently up-regulated PTEN, while inhibited Notch1, PI3K, Akt and mTOR proteins at 1.0-9.0 μM (p < 0.05). BBR also acted synergistically with Hsp90 and HDAC inhibitor (0.01 μM) in SW480 …
5. Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR …
Description: Jan 08, 2021 · Inhibition of Notch1 pathway could up-regulate the expression of PTEN. PTEN is a well-established tumour-suppressor gene which expressed in all tissues in the body, and its main target is …
6. Activation of nuclear PTEN by inhibition of Notch
Description: Mar 30, 2015 · PTEN silencing rescues Notch1-silencing-induced suppression of gastric tumor growth and clinical analysis of NICD1 and PTEN expression in malignant tissues from gastric cancer patients.
7. How does notch regulate the expression of PTEN?
Description: Interestingly, NOTCH can regulate the expression of PTEN through opposing mechanisms depending on the context.
8. How are notch and EZH2 related to breast cancer?
Description: We further find that when comparing breast cancer cases in large cohorts, EZH2 inversely correlates with PTEN expression. Within the highest EZH2 expressing group, NOTCH alterations are frequent, and also associate with decreased PTEN expression.
9. How to restore PTEN expression in breast cancer?
Description: Restoration of PTEN expression can be achieved with an EZH2 inhibitor (UNC1999), a γ-secretase inhibitor (Compound E), or knockdown of EZH2 or NOTCH.