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1. Notch1 signaling influences v2 interneuron and motor …
Description: Here we examine the role of Notch1 in the development of neuronal subtypes in the spinal cord using conditional knockout (cKO) mice lacking Notch1 specifically in neural progenitor cells. Notch1 inactivation results in accelerated neuronal …
2. Inhibition of Notch1 signaling promotes neuronal …
Description: QPCR, western blot, and immunofluorescence experiments were used to analyze Notch1 signaling pathways, RhoA, Ras homologous -associated coiled-coil containing protein kinase 1 (ROCK1), …
3. Notch1 inhibits neurite outgrowth in postmitotic primary …
Description: Jul 01, 1999 · Notch1 immunoreactivity was observed in practically all neurons, although the intensity of the staining and the pattern of subcellular Notch1 distribution varied among neurons (Fig. 2A). Both neuronal cell bodies and processes were Notch1 immunoreactive. Nuclear staining was observed in some neurons.
4. Notch1 is required for neuronal and glial differentiation in the …
Description: Jan 15, 2002 · The Notch1 gene encodes a type 1 membrane receptor of approximately 300 kDa with an N-terminal signal peptide, 36 epidermal growth factor (EGF) repeats and conserved lin/Notch repeats …
5. What does Notch 1 and Notch 3 do?
Description: There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia. Notch 1, when activated before birth, induces radial glia differentiation, but postnatally induces the differentiation into astrocytes.
6. What is the function of Notch signaling in the brain?
Description: Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. It plays a major role in the regulation of embryonic development.
7. What is the function of Notch 1 in astroglia?
Description: This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. A deficiency can be associated with bicuspid aortic valve. There is evidence that activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.
8. What kind of gene is notch homolog 1?
Description: Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor.