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1. 4851 - Gene ResultNOTCH1 notch receptor 1 [ (human)]
Description: Notch1 and NF-kappaB signaling pathways participate in bortezomib-inducing RPMI8226 cell apoptosis. review of NOTCH1 signaling in T-cell acute lymphoblastic leukemia [review] Notch1 expression were elevated in immune thrombocytopenic purpura. The positive rate of Notch1 …
2. 18128 - Gene ResultNotch1 notch 1 [ (house mouse)]
Description: Aug 24, 2021 · Notch1/NICD levels are significantly regulated by GSK-3beta and by GSK-3alpha. Notch1 rearrangement mechanisms were classified as Rag2-dependent or Rag2-independent based on the …
3. NOTCH1 (human) | Gene Target - PubChem
Description: Sep 14, 2016 · The NOTCH1 gene provides instructions for making a protein called Notch1, a member of the Notch family of receptors. Receptor proteins have specific sites into which certain other …
4. Notch1 signaling pathway promotes invasion, self-renewal ...
Description: Background: Glioma initiating cells (GICs), also known as glioma stem cells (GSCs), play an important role in the progression and recurrence of glioblastoma multiforme (GBM) due to their potential for self-renewal, multiple differentiation and tumor initiation. In the recent years, Notch1 has been found to be overexpressed in GICs. However, the regulatory mechanism of Notch1 …
5. 25496 - Gene ResultNotch1 notch receptor 1 [ (Norway rat)]
Description: Aug 22, 2021 · Notch1 protects against myocardial ischaemia-reperfusion injury via regulating mitochondrial fusion and function. Compromised Ileal Mucus Barrier Due to Impaired Epithelial Homeostasis Caused by Notch1 …
6. What are the diseases associated with the NOTCH1 gene?
Description: GeneCards Summary for NOTCH1 Gene NOTCH1 (Notch Receptor 1) is a Protein Coding gene. Diseases associated with NOTCH1 include Aortic Valve Disease 1 and Adams-Oliver Syndrome 5. Among its related pathways are Signaling by GPCR and Diseases of glycosylation.
7. What is the role of Notch receptor 1 in metastasis?
Description: PDK1 (PDPK1) promotes metastasis by inducing epithelial-mesenchymal transition in hypopharyngeal carcinoma via the Notch1 signaling pathway. Findings indicate that activation of notch receptor 1 (Notch1) signalling significantly up-regulated Netrin4 (NTN4) mRNA and protein expressions.
8. What is the role of Notch1 in cell division?
Description: Notch1 signaling helps determine the specialization of cells into certain cell types that perform particular functions in the body (cell fate determination). It also plays a role in cell growth and division (proliferation), maturation (differentiation), and self-destruction (apoptosis).
9. What does UniProtKB do for the NOTCH1 gene?
Description: UniProtKB/Swiss-Prot for NOTCH1 Gene. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus.