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1. NOTCH1 Fusion - My Cancer Genome
Description: Significance of NOTCH1 Fusion in Diseases Breast Carcinoma + NOTCH1 Fusion is an inclusion criterion in 2 clinical trials for breast carcinoma, of which 1 is open and 1 is closed.
2. A novel [email protected]/NOTCH1 fusion gene in T-cell lymphoblastic ...
Description: Conclusions: The [email protected]/NOTCH1 fusion gene with a NOTCH1 breakpoint in exon 25, which has not previously been detected in four other reported cases with t(7;9), could lead to aberrant expression of the truncated NOTCH1 by [email protected] enhancer elements. The resultant NOTCH1 receptor deleting most of the extracellular domain may be implicated in the pathogenesis of T-LBL by ligand-independent, constitutive activation of the NOTCH1 …
3. Novel MIR143-NOTCH fusions in benign and malignant glomus ...
Description: A gene fusion involving MIR143 in band 5q32 was identified in both GTs with either NOTCH2 in 1p13 in GT1 or NOTCH1 in 9q34 in GT2, but none in M1. After being validated by FISH and RT-PCR, these …
4. Notch1 Fusion Protein Ag0107 | Proteintech
Description: Notch1 fusion protein Ag0107 SDS-PAGE. Proteintech North America (HQ) Proteintech Group, Inc 5400 Pearl Street, Suite 300 Rosemont, IL 60018, USA. 1-888-478-4522 [email protected] …
5. What are the functions of the NOTCH1 gene?
Description: It also plays a role in cell growth and division (proliferation), maturation (differentiation), and self-destruction (apoptosis). The protein produced from the NOTCH1 gene has such diverse functions that the gene is considered both an oncogene and a tumor suppressor.
6. How are ligands attached to the Notch1 receptor?
Description: Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. Attachment of a ligand to the Notch1 receptor sends signals that are important for normal development of many tissues throughout the body, both before birth and after.
7. What happens when an oncogene is mutated?
Description: Oncogenes typically promote cell proliferation or survival, and when mutated, they have the potential to cause normal cells to become cancerous.