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1. Mefloquine
microsoft.com

Link: https://go.microsoft.com/fwlink/?linkid=2100071&clcid=0x409

Description: Common brand names: LariamOVERVIEWSIDE EFFECTSINTERACTIONSDOSAGEInteractionsInteractionsBefore taking this medication, tell your doctor if you've had:Mental/mood disorders (such as depression, anxiety, schizophrenia)SeizuresHeart problemsLiver disorder Mental/mood disorders (such as depression, anxiety, schizophrenia) Seizures Heart problems Liver disorder Artemether-lumefantrine Beta-blockers (such as atenolol, propranolol) Chloroquine Halofantrine Ketoconazole Quinidine Quinine Drugs for seizures (such as phenytoin, valproic acid) Ziprasidone May cause dizziness ; Medication should be taken with plenty of water. ; Take with food. ; Call your doctor immediately if you have mental/mood changes like confusion, new/worsening feelings of sadness/fear, thoughts of suicide, or unusual behavior. ; This drug may impair the ability to operate a vehicle, vessel (e.g., boat), or machinery. Use care until you become familiar with its effects. ;
Mental/mood disorders (such as depression, anxiety, schizophrenia)SeizuresHeart problemsLiver disorderArtemether-lumefantrineBeta-blockers (such as atenolol, propranolol)ChloroquineHalofantrineKetoconazoleQuinidineQuinineDrugs for seizures (such as phenytoin, valproic acid)ZiprasidoneMay cause dizziness ; Medication should be taken with plenty of water. ; Take with food. ; Call your doctor immediately if you have mental/mood changes like confusion, new/worsening feelings of sadness/fear, thoughts of suicide, or unusual behavior. ; This drug may impair the ability to operate a vehicle, vessel (e.g., boat), or machinery. Use care until you become familiar with its effects. ;
2. Mefloquine as a prophylaxis for malaria needs to be revisited
nih.gov

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342532/

Description:
3. Mefloquine: Uses, Interactions, Mechanism of Action
drugbank.com

Link: https://go.drugbank.com/drugs/DB00358

Description: WEB823 rows · Mefloquine, commonly known as Lariam, is an antimalarial drug used for the prevention and treatment of malaria caused by infection with Plasmodium vivax and Plasmodium falciparum. The drug was initially …
4. Mefloquine - Wikipedia
wikipedia.org

Link: https://en.wikipedia.org/wiki/Mefloquine

Description: OverviewMedical usesAdverse effectsContraindicationsPregnancy and breastfeedingPharmacologyHistoryResearchMefloquine, sold under the brand name Lariam among others, is a medication used to prevent or treat malaria. When used for prevention it is typically started before potential exposure and continued for several weeks after potential exposure. It can be used to treat mild or moderate malaria but is not recommended for severe malaria. It is taken by mouth. Pregnancy category: AU: B3 Formula: C₁₇H₁₆F₆N₂O Trade names: Lariam, Mephaquin, Mefliam, others
Pregnancy category: AU: B3Formula: C₁₇H₁₆F₆N₂OTrade names: Lariam, Mephaquin, Mefliam, others
5. Mefloquine - Assessment of Long-Term Health Effects of …
nih.gov

Link: https://www.ncbi.nlm.nih.gov/books/NBK556592/

Description: WEBFeb 25, 2020 · The mefloquine dosing regimen for malaria prophylaxis begins with taking one tablet (250 mg salt in the United States or 228 mg base) once a week, starting two weeks … Published: 2020/02/25
Published: 2020/02/25
6. Mefloquine as a prophylaxis for malaria needs to be revisited
nih.gov

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8342532/

Description: WEBJun 24, 2021 · Mefloquine still remains indicated for malaria prophylaxis for long-term use. Chemoprophylaxis of malaria can be achieved, especially in chloroquine-resistant P. … Author: Sundus Shafat Ahmad, Manju Rahi, Vikash Ranjan, Amit Sharma DOI: 10.1016/j.ijpddr.2021.06.003 Publish Year: 2021 Published: 2021/12
Author: Sundus Shafat Ahmad, Manju Rahi, Vikash Ranjan, Amit SharmaDOI: 10.1016/j.ijpddr.2021.06.003Publish Year: 2021Published: 2021/12
7. mefloquine (Rx) - Medscape Drugs & Diseases
medscape.com

Link: https://reference.medscape.com/drug/mefloquine-342689

Description: WEB250mg. Acute Malaria Infections. Indicated for the treatment of mild-to-moderate acute malaria caused by mefloquine-susceptible strains of P. falciparum (both chloroquine …
8. Antimalarial Medications - StatPearls - NCBI Bookshelf
nih.gov

Link: https://www.ncbi.nlm.nih.gov/books/NBK470158/

Description: WEBAug 8, 2023 · Atovaquone-proguanil plus primaquine phosphate. Mefloquine plus primaquine phosphate. Mefloquine’s antimalarial effects are similar to quinine sulfate’s effects listed above. Quinidine gluconate is the drug of …
9. Pharmacology of Antimalarial Drugs, Current Anti-malarials
springer.com

Link: https://link.springer.com/referenceworkentry/10.1007/978-1-4614-8757-9_149-1

Description: WEBFeb 28, 2019 · Mefloquine is a potent and long-acting blood schizontocidal antimalarial against all human species of Plasmodium including multidrug-resistant strains of P. …
10. Mefloquine targets the Plasmodium falciparum 80S …
nature.com

Link: https://www.nature.com/articles/nmicrobiol201731

Description: WEBMar 13, 2017 · Nature Microbiology - Cryo-EM reveals one mechanism of action of the antimalarial mefloquine: mefloquine binds to the Plasmodium falciparum 80S ribosome, inhibiting protein synthesis in the...
11. Mefloquine | The BMJ
bmj.com

Link: https://www.bmj.com/content/308/6924/286

Description: WEBJan 29, 1994 · Peer review. N J White. Mefloquine is a quinoline-methanol compound structurally related to quinine. 1 It is active against all the human malaria parasites, …
12. Review of the mechanism underlying mefloquine-induced
nih.gov

Link: https://pubmed.ncbi.nlm.nih.gov/33905310/

Description: WEBMefloquine, a potent blood schizontocide, is effective against drug-resistant <i>Plasmodium falciparum.</i> This property, along with its unique pharmacokinetic profile, makes …