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1. KRAS mutation: from undruggable to druggable in cancer
nature.com
Link: https://www.nature.com/articles/s41392-021-00780-4
Description: WebNov 15, 2021 · Kirsten rat sarcoma viral oncogene homologue (KRAS) is the best-known oncogene with the highest mutation rate among all cancers and is associated with a series of highly fatal cancers,...
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2. KRAS - Wikipedia
wikipedia.org
Link: https://en.wikipedia.org/wiki/KRAS
Description: WebKRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus. These signals instruct the cell to grow and divide (proliferate) or to mature and take on specialized functions (differentiate).
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3. Oncogenic KRAS: Signaling and Drug Resistance - PMC
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616169/
Description: WebNov 9, 2021 · KRAS protein contains 188 amino acids, with a molecular mass of 23.2kDa, and is performed as the first sensor of intracellular signaling pathway [ 2, 4 ]. Activation of KRAS is regulated by the on-off switch, resulting in an intracellular effector pathway.
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4. KRAS gene: MedlinePlus Genetics
medlineplus.gov
Link: https://medlineplus.gov/genetics/gene/kras/
Description: WebThese proteins play important roles in cell division, cell differentiation, and the self-destruction of cells (apoptosis). The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. Learn about this gene and related health conditions.
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5. Targeting KRAS in Cancer: Promising Therapeutic Strategies
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999304/
Description: WebMar 10, 2021 · Since the Kirsten rat sarcoma viral oncogene homolog (KRAS) is mutated in about 25% of all human cancers and is at the center of pathways involved in tumorigenesis, it is necessary to compile and highlight the novel therapeutic strategies behind targeting this oncoprotein in cancer.
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6. The current understanding of KRAS protein structure and dynamics
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965201/
Description: WebDec 26, 2019 · GTPase KRas (KRAS) is a signal transducer protein, which plays an important role in various cellular signalling events such as in regulation of cell proliferation.
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7. Building insights into KRAS signaling complexes - Nature
nature.com
Link: https://www.nature.com/articles/s41594-021-00631-4
Description: WebOct 8, 2021 · KRAS is a membrane-localized GTPase that oscillates between active GTP-bound and inactive GDP-bound states and functions as a critical node in growth factor receptor signaling pathways. To...
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8. The origins and genetic interactions of KRAS mutations are ... - Nature
nature.com
Link: https://www.nature.com/articles/s41467-021-22125-z
Description: WebMar 22, 2021 · When mutated at one of its four hotspot codons—12, 13, 61, or 146—activated KRAS protein hyperactivates many downstream effector pathways, such as the MAPK and PI3K-AKT signaling pathways 1.
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9. Researchers Uncover New Findings about KRAS, an Important …
mskcc.org
Link: https://www.mskcc.org/news/researchers-uncover-new-findings-about-kras-important-protein
Description: WebIn a study published October 8, 2021, in Science, researchers from Memorial Sloan Kettering Cancer Center took a closer look at what KRAS proteins do in normal cells and how certain mutations change them in a way that makes them essential for cancer growth.
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10. Understand KRAS and the Quest for Anti-Cancer Drugs - PMC
nih.gov
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068306/
Description: WebApr 8, 2021 · This review provides an overview of the structure of KRAS and its characteristic signaling pathways. Additionally, we examine the problems associated with currently available KRAS inhibitors and discuss promising avenues for drug development.
