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1. Circulating free DNA - Wikipedia
Link: https://en.wikipedia.org/wiki/Circulating_free_DNA
Description: WEBCirculating free DNA (cfDNA) (also known as cell-free DNA) are degraded DNA fragments released to body fluids such as blood plasma, urine, cerebrospinal fluid, etc. Typical sizes of cfDNA fragments reflect chromatosome particles (~165bp), as well as multiples of nucleosomes, which protect DNA from digestion by apoptotic nucleases. [1]
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2. Cell-free DNA analysis in current cancer clinical trials: a review
Link: https://www.nature.com/articles/s41416-021-01696-0
Description: WEBJan 13, 2022 · These clinical trials show promising results for the early detection of cancer and confirm cfDNA as a tool for real-time monitoring of acquired therapy resistance, accurate disease-progression...
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3. What is Cell-Free DNA (cfDNA)? – Seq It Out #19
Link: https://www.thermofisher.com/blog/behindthebench/what-is-cell-free-dna-cfdna-seq-it-out-19/
Description: WEBFeb 1, 2017 · Cell-free DNA (or cfDNA) refers to all non-encapsulated DNA in the blood stream. A portion of that cell-free DNA originates from a tumor clone and is called circulating tumor DNA (or ctDNA). cfDNA are nucleic acid fragments that enter the bloodstream during apoptosis or necrosis.
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4. Prenatal Cell-Free DNA Screening: MedlinePlus Medical Test
Link: https://medlineplus.gov/lab-tests/prenatal-cell-free-dna-screening/
Description: WEBA cfDNA screening is most often used to show if your unborn baby has an increased risk for one of the following chromosome disorders: Down syndrome (trisomy 21) Edwards syndrome (trisomy 18) Patau syndrome (trisomy 13) The screening may also be used to: Determine a baby's gender (sex).
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5. Cell-Free DNA: Hope and Potential Application in Cancer
Link: https://www.frontiersin.org/articles/10.3389/fcell.2021.639233/full
Description: WEBFeb 22, 2021 · Cell-free DNA (cfDNA) is easily accessible in peripheral blood and can be used as biomarkers for cancer diagnostics, prognostics, and therapeutics. The applications of cfDNA in various areas of cancer management are attracting attention.
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6. A hitchhiker’s guide to cell-free DNA biology - PMC
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650475/
Description: WEBNov 11, 2022 · This guide will provide the keys to read, decode, and harness cfDNA biology: the diverse sources of cfDNA in the bloodstream, the mechanism of cfDNA release from cells, the cfDNA structure, topology, and why accounting for cfDNA biology matters for clinical applications of liquid biopsy.
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7. cfDNA Sequencing: Technological Approaches and Bioinformatic …
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234829/
Description: WEBJun 21, 2021 · Cell free circulating DNA (cfDNA) refers to DNA fragments present outside of cells in body fluids such as plasma, urine, and cerebrospinal fluid (CSF). CfDNA was first identified in 1948 from plasma of healthy individuals .
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8. Evaluating the quantity, quality and size distribution of cell-free …
Link: https://www.nature.com/articles/s41598-020-69432-x
Description: WEBJul 28, 2020 · Cell-free DNA (cfDNA) has become a comprehensive biomarker in the fields of non-invasive cancer detection and monitoring, organ transplantation, prenatal genetic testing and pathogen detection.
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9. Circulating cell-free DNA for cancer early detection - PMC
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9133648/
Description: WEBJul 7, 2022 · Among them, cfDNA, which is extracellular nucleic acid fragments shed by cancer cells during apoptosis, necrosis, or secretion, is the most promising for detecting early stage cancers ( Figure 1 ). cfDNA exhibits the genetic and epigenetic alterations of cancers, including mutations, copy number alterations, chromosomal rearrangements, …
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10. At the dawn: cell-free DNA fragmentomics and gene regulation
Link: https://www.nature.com/articles/s41416-021-01635-z
Description: WEBNov 23, 2021 · Circulating cell-free DNA (cfDNA) in the peripheral blood offers a promising and non-invasive approach to monitoring the genome dynamics from the inaccessible human tissues [ 16, 17, 18 ].
